an unusual presentation of herpes simplex virus infection

HSV-2 DNA was demonstrated in the CSF by polymerase chain reaction (PCR) amplification. Examination of cerebrospinal fluid yielded mononuclear pleocytosis, elevated protein and increased IgM antibodies to herpes simplex virus (HSV) by enzyme immunoassay. Using MEDLINE, we conducted a comprehensive review of other published cases of HSV brainstem encephalitis. The case highlights the importance of testing for HSV-1 and CMV in HIV-infected patients presenting with an isolated brainstem syndrome. Neurons and glial cells in the cerebral cortex and brainstem contained herpesvirus antigens. None of the 34 cases was labeled for CMV DNA and none revealed HSV or CMV antigens. First, the lesions were symmetrical.

An isoelectric focusing-antigen overlay (IEF-O) technique showed that the target of one of the four cerebrospinal fluid oligoclonal bands was herpes simplex virus (HSV)-1 glycoprotein B, indicating a specific anti-HSV immunoresponse restricted to the CNS. Tyler and Levin), Microbiology and Immunology (Dr. The patient had a vesicular lesion on her nose. Examination of cerebrospinal fluid yielded mononuclear pleocytosis, elevated protein and increased IgM antibodies to herpes simplex virus (HSV) by enzyme immunoassay. An isoelectric focusing-antigen overlay (IEF-O) technique showed that the target of one of the four cerebrospinal fluid oligoclonal bands was herpes simplex virus (HSV)-1 glycoprotein B, indicating a specific anti-HSV immunoresponse restricted to the CNS. October 12, 2010. The patient had a vesicular lesion on her nose.

Links to PubMed are also available for Selected References. Full text Full text is available as a scanned copy of the original print version. According to the diagnostic criteria put forward by Odaka et al. C.; CAVANAGH, N.; WILSON, J.; MARSHALL, W. The finding that HPV DNA was detected more frequently in spontaneous miscarriages compared to voluntary abortions led to the consideration that HPV may be involved in the pathophysiology of early pregnancy loss [70]. Received December 28, 1994. Cold sores are considered to be caused by the Herpes Simplex what does very mild herpes look like virus, and this mostly happens when the malware is replicating other new viruses.

HSV invades the raphe nuclei after its entry into the brain stem. A 2-year-old boy presented with rapidly progressive ophthalmoplegia, ataxia, hyporeflexia, weakness of the lower extremities, and, subsequently, disturbance of consciousness. The patient was suspected of having aseptic meningitis, and brainstem involvement by neurological examination The patient was hospitalized, and gradually improved after steroid and acyclovir treatmen. High IgG anti-GQ1b antibody titers were present in all 3 sera samples but decreased with the clinical course of the illness. Oral aphtha appeared again on February 1988 followed by resistant fever to antibiotics and right hemiparesis. The patients were subjected to clinical examination, CT or MRI scan, EEG, motor and somatosensory evoked potentials in both upper and lower limbs bilaterally and concentric needle electromyography. Her findings of BBE largely resolved, although she remained with T6 American Spinal Injury Association (ASIA) A paraplegia.

Hypotonia and sleep hypoventilation, necessitating artificial ventilation during sleep, still persist. Recurrent brainstem encephalitis associated with herpes simplex virus type 1 DNA in cerebrospinal fluid. The difference is that patients with Bickerstaff’s brainstem encephalitis have impaired consciousness, whereas patients with Miller Fisher syndrome have alert consciousness and areflexia. An anti-GQ1b antibody syndrome has been proposed to underlie the common pathophysiology for the three disorders; however, other studies have found a positive anti-GM1 instead of anti-GQ1b antibody. Objectives: To report and discuss magnetic resonance imaging (MRI) findings and clinical features in atypical brainstem encephalitis and facial palsy associated with HSV-2. He needed more sleep, started to shake and fainted twice. None of the 34 cases was labeled for CMV DNA and none revealed HSV or CMV antigens.

Ophthalmoplegia has been reported with acute ataxia in Miller Fisher syndrome (MFS) and Bickerstaff brainstem encephalitis (BBE). Several studies have linked viral infection to the modulation of ganglioside expression such as human T-lymphotropic virus to GD2 and simian virus 40 to GM3. Although the clinical diagnosis of most cases of HSV-caused neurological disease is eased by the presence of clinical symptoms and brain lesions (such as focal necrosis), PCR for HSV DNA detection in CSF specimens is especially valuable in those cases in which atypical clinical and neuroradiological findings are observed. J Infect Dis. The extent of CNS demyelination is less in the immune-deficient athymic mice 7 days after infection compared to the immune-competent Balb/c mice. To report the clinical and radiologic findings of children with NMDA receptor (NMDAR) antibodies and white matter disorders. Your library or institution may give you access to the complete full text for this document in ProQuest.

Objective To describe the course of a patient with severe BBE and multiple medical complications. McLeod et al. Author manuscript; available in PMC 2016 Jul 11. Bickerstaff and Cloake1 speculated that the aetiology of BBE is similar to that of Guillain-Barré syndrome (GBS) because areflexia and CSF albuminocytological dissociation was detected in one of their three patients.