Meanwhile, the UL41 (VHS) tegument specifically degrades some mRNAs to the benefit of the virus (93, 94). Dexamethasone, given 4 months after clinical recovery, resulted in reisolation of MCF virus from blood and recrudescence of clinical MCF. This study tested the neutralizing activity of serum and plasma from select MCFV-infected reservoir hosts against alcelaphine herpesvirus 1 (AlHV-1) and ovine herpesvirus 2 (OvHV-2). Alhe1, Alcelaphine herpesvirus 1; Athe3, Ateline herpesvirus 3; Bhe1, Bovine herpesvirus 1; Bhe4, Bovine herpesvirus 4; Bhe5, Bovine herpesvirus 5; Cahe3, Callitrichine herpesvirus 3; Ccy, Chimpanzee cytomegalovirus; Cehe1, Cercopithecine herpesvirus 1; Cehe15, Cercopithecine herpesvirus 15; Cehe16, Cercopithecine herpesvirus 16; Cehe2, Cercopithecine herpesvirus 2; Cehe8, Cercopithecine herpesvirus 8; Cehe9, Cercopithecine herpesvirus 9; Ehe1, Equid herpesvirus 1; Ehe2, Equid herpesvirus 2; Ehe4, Equid herpesvirus 4; Ghe1, Gallid herpesvirus 1; Ghe2, Gallid herpesvirus 2; Ghe3, Gallid herpesvirus 3; Hhe1, Human herpesvirus 1 (HSV-1); Hhe2, Human herpesvirus 2 (varicella zoster virus, VZV); Hhe3, Human herpesvirus 3; Hhe4, Human herpesvirus 4 (EBV); Hhe5A, Human herpesvirus 5 strain AD169 (HCMV); Hhe5m, Human herpesvirus 5 strain Merlin (HCMV); Hhe6A, Human herpesvirus 6A; Hhe6B, Human herpesvirus 6B; Hhe7, Human herpesvirus 7; Hhe8, Human herpesvirus 8 (KSHV); Mehe1, Meleagrid herpesvirus 1; Mfu, Macaca fuscata rhadinovirus; Mhe2, Murid herpesvirus 2 (RCMV); Mhe4, Murid herpesvirus 4 (MHV-68); Ohe2, Ovine herpesvirus 2; Phe1, Psittacid herpesvirus 1; Rmo, Rhesus monkey rhadinovirus H26-95; Sahe2, Saimiriine herpesvirus 2; Suhe1, Suid herpesvirus 1; Tni, Trichoplusia ni ascovirus 2c; Tohe, Tortoise herpesvirus; Tuhe, Tupaia herpesvirus. The putative novel goat herpesvirus from which these sequences originate was tentatively designated caprine herpesvirus 2. A consistent theme in experimental studies of OvHV-2 in susceptible species is that there are 2 peaks of OvHV-2 gene expression: a preclinical peak involving the respiratory tract and a second in multiple organ systems leading to clinical disease. Panel B shows the same tree collapsed to form multifurcations at four locations of uncertainty in the NJ-ML analysis.
When anatomically modern humans first crossed over the Red Sea 60,000 years ago, VZV was carried along in their dorsal root ganglia. Malignant catarrhal fever is generally fatal and occurs following infection with certain herpes viruses of the genus Macavirus. As of July 2001, the VirOligo database contains a complete listing of oligonucleotides specific to viral agents associated with bovine respiratory disease that were published in English in peer-reviewed journals. Multifocally, colonic crypts contain neutrophils and cellular debris (crypt abscesses). In susceptible animals MCF viruses cause systemic infection with catarrhal inflammation of mucosal epithelium and vasculitis. There is a minimal amount of fibrin in the anterior and posterior chambers that is admixed with few lymphocytes and macrophages. (2000) 97:5756-5761.
In susceptible ruminants, OvHV-2 and AlHV-1 induce the sheep-associated form and the wildebeest-derived form of MCF (WD-MCF), respectively. Expression of hemagglutinin-tagged BILF1 in the HEK293 epithelial cell line revealed that BILF1 is expressed as an approximately 50-kDa glycosylated protein. 409-419. This AHV-1 cDNA clone expressed a fusion protein that was recognized by serum from a naturally and asymptomatically infected white-bearded wildebeest (Connochaetes taurinus albojubatus). For example, a new gene predicted in the genome of the Epstein–Barr virus was shown to encode a protein similar to α‐herpesvirus minor tegument protein UL14 with heat shock functions. Virus isolation was successful in two of the clinical cases and all cattle seroconverted. The variable pathology induced by the three viruses may reflect a quantitative or qualitative differences in this proposed activator.
We propose, on the basis of biological and structural properties, that AHV-1 be included within the gamma 2 group of herpesviruses of which herpesvirus ateles is the prototype. To reach that goal, we performed multi-colour flow cytometry stainings. (i) AlHV-1 infection induces CD8(+) T cell proliferation detectable as early as 15 days post-inoculation. The 115-kDa protein was cleaved to form a disulfide-linked heterodimer of 78 and 48 kDa, which was the mature form of the molecule incorporated into the virion envelope. 246-54. The nested PCR was more sensitive (approximately with 1 log) than the real-time PCR. VAT registration number GB 663 8239 11.
J. Some protected animals showed transient low levels of viral DNA in blood samples and in one lymph node sample after challenge whereas viral DNA was detected in the blood and in lymph node samples of all animals with MCF. The results confirm a terminal location for the repeat sequences. This was estimated to correspond to one diploid bovine cell. Tests employing three other bovid herpesviruses were negative and no reaction was found with sera from normal hamsters. Differing provisions from the publisher’s actual policy or licence agreement may be applicable. The history and clinical features included pyrexia, cornel opacity, nasal discharges, multifocal buccal ulceration of varying size and general unthrifty.
Alcelaphine herpesvirus-1 (AlHV-1) is a similar MCF virus that is carried asymptomatically by wildebeest. There are two endemic forms of MCF with distinct geographical distributions; Alcelaphine herpesvirus 1 (AlHV-1), which is endemic in wildebeest and causes the wildebeest-associated form of MCF in cattle and other species.