OKC Zoo elephant tests positive for herpes virus

31:518-522. Maes, M. CrossRef, PubMed Ganheim, C., S. Q9. Evidence of EEHV1 infection in South India is particularly concerning because the region holds the largest population of Asian elephants. First round PCR B1/A2 575 base pair (bp); second round A3/B2 415 bp; A3SEQ/B2SEQ = 360 bp. Whole-genome shotgun phage M13-based sequencing has been routinely and successfully accomplished for all nine human and numerous animal herpesviruses of veterinary or agricultural interest.

Fringe extremist organizations do not have the expertise or credentials to comment on the care and conservation of elephants. The work will start as soon as 30% of the requested funding is achieved. One survived. Hayward speculates that perhaps elephants are more likely to survive a primary infection if they are still armed with maternal antibodies, acquired both across the placenta and from their mothers’ milk. Faecal glucocorticoid levels (for those time periods for which they were available) and behavioural records were also examined to analyse physiological or behavioural indicators of stress that may be linked with EEHV-1 shedding. It may also now be quite plausible and desirable to determine the EEHV-1 positive or negative status of all Asian elephant calves under human care. Hayward, ghayward{at}jhmi.edu.


The efficacy of FCV treatment to curb progression to EEHV-HD in clinical EEHV has always been debatable, as compromised cellular function at enteric level could affect absorption. If, however, the elephant is in the sun and can still walk, take it to the nearest shady place (no further than 100 metres). Y. C. This is a partially funded project and the candidate is required to cover cost of living and registration with University of Surrey, www.Surrey.ac.uk. Richman, J.-C. Preliminary results suggest 5 mg/kg orally will result in drug levels that should be therapeutic in elephants (Ramiro Isaza, Kansas State University, personal communication).

Instead, both the virus and the disease are evidently widespread in Asia and, despite the disease severity, Asian elephants appear to be the ancient endogenous hosts of both EEHV1A and EEHV1B. Nor can they say whether it will remain dormant after its initial assault only to re-emerge, like some herpes viruses in humans. Transmission electron microscopy of the endothelial inclusion bodies revealed 80 to 92 nm diameter viral capsids consistent with herpesvirus morphology. Clinical EEHV disease can be very rapid, beginning with oedema of head and thoracic limbs, lethargy, anorexia and reluctance to drink, and progressing to ulceration and cyanosis of the tongue, and internal organ haemorrhage. “We were still pretty sad but grateful to find out the cause,” Bohmke said Monday. In a paper summarised on p 205 of this week’s Veterinary Record, Hardman and others (2011) use a Taqman PCR assay to add evidence to the idea that asymptomatic infections with EEHV-1 may indeed be common and possibly nearly universal in adult Asian elephants in a UK zoo herd. Tuberculosis is difficult to diagnose in elephants, and current diagnostic tools have limitations.

Identification of Candidate Proteins for an EEHV Vaccine Elephant Endotheliotropic Herpesvirus (EEHV) is one of the most significant causes of mortality in young Asian elephants. 13523–13546 and p. Three affected young Asian elephants recovered after a 3–4-week course of therapy with the anti-herpesvirus drug famciclovir [Richman et al., J Wildl Dis 36:1–12, 2000; Schmitt and Hardy, J Elephant Managers Assoc 9:103–4, 1998]. Among a total of 119 genes with an overall colinear organization similar to those of the AT-rich EEHVs, major features of EEHV4 include a family of 26 paralogous 7xTM and vGPCR-like genes plus 25 novel or missing genes. Here, we focus on glycoprotein B (gB) for serologic assay development, since gB is an envelope protein known to induce a neutralising antibody response in other herpesvirus infections. The zoo launched a partnership with the Gulf Coast Regional Blood Center on Tuesday to stop the virus from killing any more. In Thai, her name meant flower and Malee the elephant fit the bill perfectly, becoming one of the most popular animals at the Oklahoma City Zoo during her short life.

IEF is governed by a diverse group of highly regarded elephant professionals representing captive management, zoo administration, veterinary medicine, science, and private facilities, combining years of experience with multi- disciplinary expertise in the care and management of African and Asian elephants. 17-18. EEHV1 does not replicate in culture and little is currently known about the molecular biology of this emerging pathogen, with the notable exception of its genomic DNA sequence. Across the world, elephant endotheliotropic herpesvirus is increasingly killing elephant calves and threatening the long-term survival of the Asian elephant, a species that is currently facing extinction. Elephant endotheliotropic herpesvirus 1A is a member of the Proboscivirus genus and is a major cause of fatal hemorrhagic disease in endangered juvenile Asian elephants worldwide. The animal care team of the Oklahoma City Zoo and Botanical Garden has detected, through routine testing, the active presence of the elephant endotheliotropic herpesvirus (EEHV), 1A strain, in its youngest Asian elephant, 21-month-old female Achara.